Healthcare

Uh-Oh, Big French Pharma Linked to US Healthcare Protests

In an almost satirical twist to the healthcare debate, it turns out that Big French Pharma, in the form of Sanofi-Aventis (SNY), is now linked to anti-Obamacare protests via lobbying firm DLA Piper.

DLA ex-employee Dick Armey is chairman of Freedomworks, a pressure group that organizes town hall yell-ins. He was just forced to resign from DLA last week as a result of this relationship when Bristol-Myers (BMY) was recently found linked to Freedomworks through DLA as well.

It's doubtful that any fees paid by Sanofi or Bristol to DLA Piper actually funded Freedomworks, but even just the appearance of conflict is enough to cause damage. It will be easy for pharma opponents to make accusations since, for example, on just one Medicare reform issue Bristol Meyers and Sanofi stand to lose over $500 million dollars of revenue.

Goldman: Please Keep Trading the China Bubble

 Sometimes "professional" investment research resembles little more than a day trader rag with nicer charts and fancier wording to make the reader feel less guilty and more professional about the kind of "investing" he or she is actually performing. Thus we point to Goldman's recent China "Portfolio Strategy" dated July 31st where they tell us to basically keep buying the Chinese market based on government support for the economy and a "favorable liquidity setup". We're told to buy on dips, "stay engaged" (ie. keep generating commissions), and trade earnings suprises. Is this professional investing or what your college roommate was doing during the dotcom bubble? It's hard to tell the difference.

Market view: Stay invested; buy on dips for new money A-share market gained 12.4% in July despite a 5.3% correction, which was provoked by concerns regarding credit tightening, on July 29. We maintain our positive market view on A shares and think the government’s pro-growth policy stance, which should ultimately lead to macro/earnings recovery and a favorable liquidity setup, will continue to bode well for equities.That said, we see price volatility nudging higher as uncertainties revolving around interim earnings and the government’s monetary policy stance intersect with an above-mid-cycle multiple (24x). We would stay engaged in the market and look for opportunities to accumulate positions on dips.

Strategies: Domestic demand exposure; Trade earnings surprises We recommend investors to focus on the following themes to gain exposure to the A-share market: (1) Laggards with valuation buffers and reasonable EPS growth; (2) Pro-cyclical domestic demand, which includes banks, insurance, property, and selected consumer and materials names; (3) Stocks that are potentially subject to positive earnings surprises.

That's the front page: trust the government to support the market, trust dumber investors to follow you (liquidity) and try to make little earnings trades hoping for pops. Oh wait. What about valuations?

Valuations: Above mid-cycle, but may persist CSI300 is now trading at around 23.9x I/B/E/S consensus P/E and 3.2X P/B on a 12-month forward basis against an average of 18.9x and 2.0x since April 2005, respectively (see Exhibits 1 and 2). On the basis that FY09 EPS growth for the aggregate market could be lower than the 15% that I/B/E/S consensus is currently forecasting, the forward P/E for CSI300 would be even higher at around 26.6x using our FY09 EPS growth assumption of - 5%. July 31, 2009

So valuations are sky high and earnings estimates might be missed. But we should hang on, because high valuations may persist. That's our upside investment case. High valuations may persist... and actually need to go higher or have upside earnings surprises to really give us upside on stock prices since they are already stretched as it is. Also, note that they compare recent valuation multiples to the average since... only 2005.. which was still a pretty bullish period for Chinese equities. So valuations are stretched even above what we saw during a pretty bullish time for China, but we should just have confidence in the government and liquidity to keep pushing things higher. This is what we are made to believe is "professional investing" rather than a gambler's punting.

Why European Markets Could Double

Take the ten-year average profitability and apply it to European companies as a way to normalize earnings. And you get a market discounted below the long term moving average says Peter Oppenheimer of Goldman Sachs. The conclusion? European markets could double if valuations mean-revert.

Assuming, as we do, that ROE mean reverts to long run averages by then, we estimate the broader European market to double (420 on the DJ Stoxx 600).

Biologic Drugs With Highest Expected Sales Won't Be Owned By Biotech Companies

To me this shows us that biotech isn't just an offshoot of pharma anymore. It is pharma. It's the more sophisticated an effective way for drugs to be developed. Perhaps soon we won't even make the distinction between biotech and old "chemistry-based" pharma. They'll all just be pharma (though the distinction between small innovative companies and large pharma marketing platforms, Big Pharma, will continue to apply) This is because most future discoveries are likely to be biotech-based. This also shows, as the linked article says, that right now "Biotech is good at making drugs and Big Pharma is good at selling them".

Pfizer Plans to Build a 100-Strong Twitter PR Army

Pfizer has launched a Twitter account and wants to see an army of 100 execs contributing to its tweet stream. If that happened, it would be reminiscent of an idea floated by a consultant to Johnson & Johnson in 2007. That consultant urged J&J to give all of its 120,000 employees their own blog. (Thus far, J&J has had two blogs, one of which died.)

"I would love to have by the end of the summer 100 people, from medical to public affairs, who have been anointed by the company and who can go out and Twitter."

I'm curious to see what kind of messages a Pfizer tweet stream would contain. "Neato just injected a test sbjct w/ CD4X-15 and no signs of seizure!"

Merck and Schering M&A: Schering the Weaker Player

A comparison of Merck and Schering-Plough's Q2 2009 results shows that both companies' sales force productivity is flatlining, but that Schering is the weaker partner going into their merger...

Challenging Expectations Baked Into Asian Markets for 2009

Has hope returned a bit too fast to Asian markets? To answer this question, Citi Investment Research's Asia Ex-Japan strategist Mr. Markus Rosgen put out a piece that asks some tough questions of current Asian market bulls, warning that the risk of missing 2009 earnings expectations is high. ("V-Shaped Recovery Priced In; Companies Had Better Deliver".)

Simply put, in Asia, analyst estimates have been revised substantially as of late. So much that 2009 EPS growth is now set at -2%, which is essentially asking for flat year. On this Mr. Rosgen puts forth an interesting point. If these analysts' estimates turn out to be correct, then the current downturn would have seen only one year of substantial earnings decline, in 2008. We would then have a sharp V-shaped recovery... so much that current estimates are projecting 30% earnings growith in 2010. Thus analysts as a whole are saying 2008 was 30% down (historical fact), then we're flat in 2009, then running back to 30% growth in 2010? Hmmm. Maybe. I hope so. But definitely seems like a challenging set of expectations for Asian listed companies going forward. This would make it the "shortest and shallowest" recession since 1975. From an ROE perspective, it would also be doing pretty well vs. history. Analyst estimates have ROE for Asia troughing at 9.3% vs. 4.7% during the last downturn in 1998. What this means is that if Asian bulls turn out correct, then this will truly be an extraordinary recovery from one of the worst global slow-downs to date. Seems like the kind of speculation where the facts and history are stacked against you...

Given where revisions are today, though, the probability of disappointment is much higher than the probability of a positive surprise. Now, analysts are projecting a mere 2% decline in earnings for 09, followed by a 30% increase in 2010. On this view, the recovery is V-shaped. To labour the point, that's a 30% decline in earnings in 2008, essentially flat in 09 and a 30% increase in 2010. Great if it happens. But how realistic is it? And what needs to happen for it to be achieved?

FDA Re-Branding the Black Box Warning: How to Make Potential Death More Palatable

Black Box warnings are the most severe type of warning that the FDA can require for a pharmaceutical. They can indicate a wide range of potential risks, with varying degrees of probability, but one thing is for sure. The the term Black Box is downright scary and it frequently highlights a serious, though perhaps very improbable, health risk such as, well, death.

Still, to be fair, it could be simply telling me about a suicide risk that has 1/100th the probability of me similarly dying when I get behind the wheel of a car. And given the dark name, I'm far less inclined to risk the Black Box warning than to drive to the corner store. So perhaps this is a problem, that the term Black Box is too scary even if it does warn of some pretty unfortunate risks.

It appears the FDA has recognized this since they are beginning to phase-out the term with some better word choice. Is it fair if we call this a re-branding of the Black Box?

On the FDA conference call with reporters this afternoon to discuss the new warnings, two agency officials told the news media to use the phrase "Boxed warning" instead of "Black box warning." Why? As one of them put it, "Black box carries the implication, 'Don't you dare use this'." The other official added, "We don't want to scare people off (from trying to quit smoking). We just want them to be carefully monitored."

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